NOTE: This is NOT a complete list, and it’s very important to provide ICS with a complete list of any of the following substances that you’re taking:

  • Street Drugs
  • Prescription medications
  • Over the counter medications
  • Supplements

When metabolized by the liver, Ibogaine gets converted into its metabolite 12-hydroxyibogamine (noribogaine). Metabolism of ibogaine occurs mainly through two (or more) enzymes catalyzed by cytochrome P4502D6 (CYP2D6). The CYP2D6 enzymes are used to metabolize many medications, certain supplements, and as well foods. When combined with ibogaine the following medications listed can prolong QT intervals, cause cardiac arrhythmias, and cause other negative effects.

Cytochrome P4502D6 (CYP2D6) blockers/competitors

Anti-arrhythmic drugs:

  • Metoprolol
  • Propafenone
  • Timolol maleate

Antidepressant drugs:

  • Amitriptyline (Elavil)
  • Citalopram (Celexa)
  • Clomipramine
  • Desipramine
  • Duloxetine (Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane)
  • Escitalopram (Lexapro)
  • Imipramine (Tofranil)
  • Paroxetine (Paxil)
  • Venlafaxine (Effexor)


  • Aripiprazole (Abilify, Aripiprex)
  • Haloperidol (Haldol)
  • Pimozide (Orap)
  • Risperidone (Risperdal)
  • Thioridazine (Mellaril, Sonapax, Thioril)

Drugs that prolong QT intervals (not a good combination with ibogaine treatment):

  • Amiodarone
  • Azithromycin (Zithromax)
  • Bepridil (Vascor)
  • Chloroquine (Aralen)
  • Chlorpromazine (Thorazine, Largactil)
  • Clarithromycin (Biaxin)
  • Disopyramide (Norpace)
  • Dofetilide (Tikosyn)
  • Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar)
  • Erythromycin (Isotrexin)
  • Flecainide acetate (Tambocor, Almarytm, Apocard, Ecrinal, Flécaine)
  • Halofantrine (Halfan)
  • Moxifloxacin (Avelox, Avalox, Avelon, Vigamox, Moxeza)
  • Pentamidine (NebuPent)
  • Procainamide (Pronestyl, Procan, Procanbid)
  • Quinidine (Quinaglute)
  • Sevoflurane (Ulane)

Other common medications that compete with the ibogaine molecule:

  • Codeine (3-methylmorphine)
  • Dextromethorphan (DXM, DM)
  • Methadone (Methadose)
  • Mexiletine (Mexitil)
  • Ondansetron (Zofran)
  • Tamoxifen (Nolvadex, Istubal, Valodex)
  • Tramadol (Ultram, Ralivia, Tramal)

Foods and drinks that contain grapefruit juice, and a variety of other supplements and over-the-counter medications such as Prilosec (Omeprazole), various gastric drugs, anti-fungal medications, HIV treatment drugs, and some antihistamines, can all contribute to significantly prolonging QT intervals and cause problems when still circulating within the body at time of ibogaine treatment.